Spanish influence in the New World was particularly acute in the areas of medicine and medical education. From the time of Columbus forward prominent medical experts journeyed to Latin America establishing medical schools and research centers. This essay chronicles the history of Latin America with a strong focus on the physicians and scientists who brought modern scientific medicine, as it wag then known in Western Europe, to the Americas.

Autism is a group of complex neurodevelopmental disorders characterized by impaired social interaction and restricted/repetitive behavior. We performed a large-scale retrospective analysis of 1,996 clinical neurological structural magnetic resonance imaging (MRI) examinations of 781 autistic and 988 control subjects (aged 0 to 32 years), and extracted regionally distributed cortical thickness measurements, including average measurements as well as standard deviations which supports the assessment of intra-regional cortical thickness variability. The youngest autistic participants (< 2.5 years) were diagnosed after imaging (...) and were identified retrospectively. The largest effect sizes and the most common findings not previously published in the scientific literature involve abnormal intra-regional variability in cortical thickness affecting many (but not all) regions of the autistic brain, suggesting irregular gray matter development in autism that can be detected with MRI. Atypical developmental patterns have been detected as early as 0 years old in individuals who would later be diagnosed with autism. (shrink)

What is the self? Does it exist? If it does exist, what is it like? It's not clear that we even know what we're asking about when we ask these large, metaphysical questions. The idea of the self comes very naturally to us, and it seems rather important, but it's also extremely puzzling. As for the word "self"--it's been taken in so many different ways that it seems that you can mean more or less what you like by it and (...) come up with almost any answer. Galen Strawson proposes to approach the (seeming) problem of the self by starting from the thing that makes it seem there is a problem in the first place: our experience of the self, our experience of having or being a self, a hidden, inner mental presence or locus of consciousness. He argues that we should consider the phenomenology (experience) of the self before we attempt its metaphysics (its existence and nature). And when we have considered what it's like for human beings (assuming we can generalize about ourselves), we need to consider what it might be like for other possible creatures: what's the very least that might count as experience of oneself as a self? This, he proposes, will give us a good idea of what we ought to be looking for when we go on to ask whether there is such a thing-an idea worth following wherever it leads. It leads Strawson to conclude that selves, inner subjects of experience, do indeed exist. But they bear little resemblance to traditional conceptions of the self. (shrink)

Magnetic resonance imaging (MRI) can provide a number of measurements relevant to sport-related concussion (SRC) symptoms; however, most studies to date have used a single MRI modality and whole-brain exploratory analyses in attempts to localize concussion injury. This has resulted in highly variable findings across studies due to wide ranging symptomology, severity and nature of injury within studies. A multimodal MRI, symptom-guided region-of-interest (ROI) approach is likely to yield more consistent results. The functions of the cerebellum and basal (...) ganglia transcend many common concussion symptoms, and thus these regions, plus the white matter tracts that connect or project from them, constitute plausible ROIs for MRI analysis. We performed diffusion tensor imaging (DTI), resting-state functional MRI, quantitative susceptibility mapping (QSM), and cerebral blood flow (CBF) imaging using arterial spin labeling (ASL), in youth aged 12-18 years following SRC, with a focus on the cerebellum, basal ganglia and white matter tracts. Compared to controls similar in age, sex and sport (N = 20), recent SRC youth (N = 29; MRI at 8 ± 3 days post injury) exhibited increased susceptibility in the cerebellum (p = 0.032), decreased functional connectivity between the caudate and each of the pallidum (p = 0.035) and thalamus (p = 0.021), and decreased diffusivity in the mid-posterior corpus callosum (p < 0.038); no changes were observed in recovered asymptomatic youth (N = 16; 41 ± 16 days post injury). For recent symptomatic-only SRC youth (N = 24), symptom severity was associated with increased susceptibility in the superior cerebellar peduncles (p = 0.011) and reduced activity in the cerebellum (p = 0.013). Fewer days between injury and MRI were associated with reduced cerebellar-parietal functional connectivity (p < 0.014), reduced activity of the pallidum (p = 0.002), increased CBF in the caudate (p = 0.005), and reduced diffusivity in the central corpus callosum (p < 0.05). Youth SRC is associated with acute cerebellar inflammation accompanied by reduced cerebellar activity and cerebellar-parietal connectivity, as well as structural changes of the middle regions of the corpus callosum accompanied by functional changes of the caudate, all of which resolve with recovery. Early MRI post-injury is important to establish objective MRI-based indicators for concussion diagnosis, recovery assessment and prediction of outcome. (shrink)

Clarke attacks Spinoza's monism on the grounds that it cannot explain how a multiplicity of things follows from one substance, God. This article argues that Clarke assumes that Spinoza's God is countable. It then sketches a way in which multiplicity can follow from God's uncountable nature.

Magnetic resonance imaging is a noninvasive imaging tool that utilizes a strong magnetic field and radio frequency waves to visualize in great detail organs, soft tissue, and bone. Unlike conventional x-rays, there is no exposure to ionizing radiation and at most field strengths the procedure is considered safe for nearly every age group. Because it is non-invasive and possesses excellent spatial resolution, the use of MRI as a research tool has increased exponentially over the past decade. Uses (...) have ranged from add-ons to a clinical study to studies of brain development in typically developing children. In addition, a major effort has been made in recent years to use MRI to study brain function. Because the clinical utility of fMRI has not yet been realized, fMRI is still considered highly exploratory, and we cannot yet identify incidental findings of a functional nature. (shrink)

ABSTRACTMost of Spinoza’s arguments for God’s existence do not rely on any special feature of God, but instead on merely general features of substance. This raises the following worry: those arguments prove the existence of non-divine substances just as much as they prove God’s existence, and yet there is not enough room in Spinoza’s system for all these substances. I argue that Spinoza attempts to solve this problem by using a principle of plenitude to rule out the existence of other (...) substances and that the principle cannot be derived from the PSR, as many claim.Abbreviation: PSR: Principle of Sufficient Reason. (shrink)

ABSTRACTWe seem to have a direct experience of our freedom when we act. Many philosophers take this feeling of freedom as evidence that we possess libertarian free will. Spinoza denies that we have free will of any sort, although he admits that we nonetheless feel free. Commentators often attribute to him what I call the ‘Negative Account’ of the feeling: it results from the fact that we are conscious of our actions but ignorant of their causes. I argue that (...) the Negative Account is flawed. The feeling of freedom also depends on a vacillation of the mind. When the mind forms too many incompatible associations, it vacillates between them. When we act, the mind vacillates back and forth between the kinds of actions that we associate with our present mental state. We then mistake this subjective vacillation for an objective feature of ourselves—namely, the power to do otherwise. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, (...) 8252 participants (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Introduction -- A default position -- Experience -- The character of experience -- Understanding-experience -- A note about dispositional mental states -- Purely experiential content -- An account of four seconds of thought -- Questions -- The mental and the nonmental -- The mental and the publicly observable -- The mental and the behavioral -- Neobehaviorism and reductionism -- Naturalism in the philosophy of mind -- Conclusion: The three questions -- Agnostic materialism, part 1 -- Monism -- The linguistic argument (...) -- Materialism and monism -- A comment on reduction -- The impossibility of an objective phenomenology -- Asymmetry and reduction -- Equal-status monism -- Panpsychism -- The inescapability of metaphysics -- Agnostic materialism, part 2 -- Ignorance -- Sensory spaces -- Experience, explanation, and theoretical integration -- The hard part of the mind-body problem -- Neutral monism and agnostic monism -- A comment on eliminativism, instrumentalism, and so on -- Mentalism, idealism, and immaterialism -- Mentalism -- Strict or pure process idealism -- Active-principle idealism -- Stuff idealism -- Immaterialism -- The positions restated -- The dualist options -- Frege's thesis -- Objections to pure process idealism -- The problem of mental dispositions -- Mental -- Shared abilities -- The sorting ability -- The definition of mental being -- Mental phenomena -- The view that all mental phenomena are experiential phenomena -- Natural intentionality -- E/c intentionality -- The experienceless -- Intentionality and abstract and nonexistent objects -- Experience, purely experiential content, and n/c intentionality -- Concepts in nature -- Intentionality and experience -- Summary with problem -- Pain and pain -- The neo-behaviorist view -- A linguistic argument for the necessary connection between pain and behavior -- A challenge -- The Sirians -- N.N. Novel -- An objection to the Sirians -- The Betelgeuzians -- The point of the Sirians -- Functionalism, naturalism, and realism about pain -- Unpleasantness and qualitative character -- The weather watchers -- The rooting story -- What is it like to be a weather watcher? -- The aptitudes of mental states -- The argument from the conditions for possessing the concept of space -- The argument from the conditions for language ability -- The argument from the nature of desire -- Desire and affect -- The argument from the phenomenology of desire -- Behavior -- A hopeless definition -- Difficulties -- Other-observability -- Neo-behaviorism -- The concept of mind. (shrink)

Cognitive phenomenology starts from something that has been obscured in much recent analytic philosophy: the fact that lived conscious experience isn’t just a matter of sensation or feeling, but is also cognitive in character, through and through. This is obviously true of ordinary human perceptual experience, and cognitive phenomenology is also concerned with something more exclusively cognitive, which we may call propositional meaning-experience: occurrent experience of linguistic representations as meaning something, for example, as this occurs in thinking or reading (...) or hearing others speak. One source of resistance to accepting this view has been a failure to distinguish sharply between cognitive content and cognitive-phenomenological content. (shrink)

This paper examines Spinoza’s view on the consistency of mental representation. First, I argue that he departs from Scholastic tradition by arguing that all mental states—whether desires, intentions, beliefs, perceptions, entertainings, etc.—must be logically consistent. Second, I argue that his endorsement of this view is motivated by key Spinozistic doctrines, most importantly the doctrine that all acts of thought represent what could follow from God’s nature. Finally, I argue that Spinoza’s view that all mental representation is consistent pushes (...) him to a linguistic account of contradiction. (shrink)

Late modernity has witnessed a growing semantic shift from “religion” to “spirituality.” In this article, I argue what underlies this shift is a cultural structure I call the religion of the heart. I begin with an explication of what I mean by the “religion of the heart,” and draw on the work of Ernst Troeltsch and Colin Campbell to identify what I take to be its historical antecedents. Second, I analyze the ambiguous relationships fostered between the religion of the (...) heart and the discourses of science and religion, respectively, in late modernity. I illuminate how the social conditions of late modernity undermine or challenge what we conventionally think of as scientific and religious authorities, while at the same time creating existential needs that the religion of the heart is well adapted to meet. I conclude with a brief discussion of the implications of this process, especially as it relates to the sustainability of science and religion, as independent enterprises, in the twenty‐first century. (shrink)

The Critical Thinking Toolkit is a comprehensive compendium that equips readers with the essential knowledge and methods for clear, analytical, logical thinking and critique in a range of scholarly contexts and everyday situations. Takes an expansive approach to critical thinking by exploring concepts from other disciplines, including evidence and justification from philosophy, cognitive biases and errors from psychology, race and gender from sociology and political science, and tropes and symbols from rhetoric Follows the proven format (...) of The Philosopher’s Toolkit and The Ethics Toolkit with concise, easily digestible entries, “see also” recommendations that connect topics, and recommended reading lists Allows readers to apply new critical thinking and reasoning skills with exercises and real life examples at the end of each chapter Written in an accessible way, it leads readers through terrain too often cluttered with jargon Ideal for beginning to advanced students, as well as general readers, looking for a sophisticated yet accessible introduction to critical thinking. (shrink)

Plato’s partition argument infers that the soul has parts from the fact that the soul experiences mental conflict. We consider an ambiguity in the concept of mental conflict. According to the first sense of conflict, a soul is in conflict when it has desires whose satisfaction is logically incompatible. According to the second sense of conflict, a soul is in conflict when it has desires which are logically incompatible even when they are unsatisfied. This raises a dilemma: if the (...) mental conflict is supposed to be the latter kind of conflict, then the partition argument is valid but is likely unsound; if it’s supposed to be the former kind, then the partition argument has true premises but is invalid. We explain this dilemma in detail and defend a dispositionalist solution to it. (shrink)

Does the self exist? If so, what is its nature? How long do selves last? Galen Strawson draws on literature and psychology as well as philosophy to discuss various ways we experience having or being a self. He argues that it is legitimate to say that there is such a thing as the self, distinct from the human being.

Clarendon Later Ancient Philosophers General Editors: Professor Jonathan Barnes, Balliol College, Oxford, and Professor A. A. Long, University of California, Berkeley This series, which is modelled on the familiar Clarendon Aristotle and Clarendon Plato Series, is designed to encourage philosophers and students of philosophy to explore the fertile terrain of later ancient philosophy. The texts will range in date from the first century BC to the fifth century AD, and they will cover all the parts and all the schools (...) of philosophy. Each volume will contain a substantial introduction, an English translation, and a critical commentary on the philosophical claims and arguments of the text. The translations will aim primarily at accuracy and fidelity; but they will also be readable and accompanied by notes on textual problems that affect the philosophical interpretation. No knowledge of Greek or Latin will be assumed. Galen's On the Therapeutic Method, written late in his life, represents the distillation in its most complete form of Galen's views on the nature, genesis, proper classification, and treatment of disease. It was one of the most widely read of all classical texts during the Middle Ages and the Renaissance, and formed the core of the medical curriculum until the seventeenth century. Although still deeply influential in the nineteenth century, it has been unjustly neglected in modern times. The work contains a fascinating collection of views on scientific terminology and taxonomy, the application of the logical methods of collection and division to science, the axiomatization of science, and the structure of causation. Consequently it is a key text in later Greek philosophy of science. R. J. Hankinson provides here the first translation into any modern language of the first two books, together with an introduction and a philosophical commentary. (shrink)

There occurred in the twentieth century the most remarkable episode in the history of human thought. A number of thinkers denied the existence of something we know with certainty to exist: consciousness, conscious experience. Others held back from the Denial, as we may call it, but claimed that it might be true --a claim no less remarkable than the Denial. This paper documents some aspects of this episode, with particular reference to two things. First, the development of two views (...) which are forms of the Denial --philosophical behaviourism, and functionalism considered as a doctrine in the philosophy of mind-- from a view that does not in any way involve the Denial: psychological methodological behaviourism. Second, the rise of a way of understanding naturalism --materialist or physicalist naturalism-- that wrongly takes naturalism to entail the Denial. (shrink)

According to Christian theology, after being properly judged, bad souls are damned to Hell for eternity after being judged. Supernatural differs in that some of the souls in Hell weren't even judged, they just made very bad deals. But regardless of whether you think the mythos of Supernatural is even correct on this point, the fact that we recognize these are very bad deals should tell us something about the choices that land us in Hell. Our attitudes toward the experience (...) of punishment highlight an interesting feature about Hell in Supernatural—a person in Hell might not be there because they lived a bad life, but because they made a really bad deal with a demon. There is a problem with justifying Hell's existence this way, which our “deals with demons” examples from Supernatural make clear. Without a doubt, Hell is fundamental to Supernatural, but is definitely not a justifiable punishment. (shrink)

No doubt the years hunting monsters and saving the universe have had their toll on the Winchesters, but their toughest and most gruesome battles are contained in this book. Think Lucifer was diabolically clever? Think again. No son is more wayward than the one who squanders his intellect and academic career pursuing questions as poignant as “Half-awesome? That’s full-on good, right?” Gathered here for the first time since the formation of Purgatory, a collection of research so arcane and horrific that (...) it would make even the late, great Bobby Singer blush. _Supernatural and Philosophy_ tackles all the big ideas in the long-running hit show _Supernatural_, covering thorny issues in a fun and accessible way. Even those unfamiliar with the show will find fascinating insights into Heaven, Hell, Angels, Demons, God, and Lucifer. A unique collection of insights into the many philosophical, religious, and paranormal topics in the hit TV show, _Supernatural_ Accessible treatment of thorny issues for a general audience Written by philosophical fans of the show, for philosophical fans of the show Those unfamiliar with the show will still find fascinating insights into Heaven, Hell, Angels, Demons, God, Lucifer, and Good and Evil Contributors tackle issues ranging from the biological classifications of monsters, to the epistemological problems of ghost hunting. (shrink)

Mauro Carbone’s most recent book, Philosophy-Screens: From Cinema to the Digital Revolution advances the work and thought of his Flesh of Images: Merleau-Ponty Between Painting a...

Disorders of consciousness (DOC) raise profound scientific, clinical, ethical, and philosophical issues. Growing knowledge on fundamental principles of brain organization in healthy individuals offers new opportunities for a better understanding of residual brain function in DOCs. We here discuss new perspectives derived from a recently proposed scheme of brain organization underlying consciousness in healthy individuals. In this scheme, thalamo-cortical networks can be divided into two, often antagonistic, global systems: (i) a system of externally oriented, sensory-motor networks (the ‘‘extrinsic’’ system); (...) and (ii) a system of inward-oriented networks (the ‘‘intrinsic’’ or default system). According to this framework, four distinct mental states would be possible that could be relevant for understanding DOCs. In normal healthy volunteers and locked-in syndrome patients, a state of high functionality of both the extrinsic and intrinsic or default systems is expected — associated with full awareness of environment and self. In this case, mental imagery tasks combined with fMRI can be used to detect covert awareness in patients that are unable to communicate. According to the framework, two complementary states of system imbalance are also possible, in which one system is in a hyperfunctional state, while the other is hypoactive. Extrinsic system hyperfunction is expected to lead to a state of total sensory-motor ‘‘absorption’’ or ‘‘lost self.’’ In contrast, intrinsic or default system hyperfunction is expected to lead to a state of complete detachment from the external world. A state where both extrinsic and intrinsic systems are hypofunctional is predicted to lead to markedly impaired consciousness as seen in DOCs. Finally, we review the potential use of ultra-slow fluctuations in BOLD signal as a tool for assessing the functional integrity of extrinsic and intrinsic systems during ‘‘resting state’’ fMRI acquisitions.. (shrink)

This article explores the question of the cognitivity of the arts. It begins from Kundera’s argument that the novel, originating from Cervantes, offers a response toGalileo and solution to Husserl’s diagnosis of a “crisis of European sciences.” Expanding to the full range of literary arts, we next undertake a re-reading of Aristotle’s Poetics to assess Aristotle’s views of the origins of tragedy and press for a cognitive interpretation of the meaning of catharsis and emotions. Finally, turning to the (...) abstract expressionism of Barnett Newman, we develop a cognitive interpretation of visual arts and the non-figurative aesthetic of the sublime. (shrink)

This article explores the question of the cognitivity of the arts. It begins from Kundera’s argument that the novel, originating from Cervantes, offers a response toGalileo and solution to Husserl’s diagnosis of a “crisis of European sciences.” Expanding to the full range of literary arts, we next undertake a re-reading of Aristotle’s Poetics to assess Aristotle’s views of the origins of tragedy and press for a cognitive interpretation of the meaning of catharsis and emotions. Finally, turning to the (...) abstract expressionism of Barnett Newman, we develop a cognitive interpretation of visual arts and the non-figurative aesthetic of the sublime. (shrink)

Several studies showed evidence supporting the possibility of hand trajectory decoding from low-frequency electroencephalography. However, the decoding in the source space via source localization is scarcely investigated. In this study, we tried to tackle the problem of collinearity due to the higher number of signals in the source space by two folds: first, we selected signals in predefined regions of interest ; second, we applied dimensionality reduction techniques to each ROI. The dimensionality reduction techniques were computing the mean, principal (...) component analysis, and locality preserving projections. We also investigated the effect of decoding between utilizing a template head model and a subject-specific head model during the source localization. The results indicated that applying source-space decoding with PCA yielded slightly higher correlations and signal-to-noise ratios than the sensor-space approach. We also observed slightly higher correlations and SNRs when applying the subject-specific head model than the template head model. However, the statistical tests revealed no significant differences between the source-space and sensor-space approaches and no significant differences between subject-specific and template head models. The decoder with Mean and PCA utilizes information mainly from precuneus and cuneus to decode the velocity kinematics similarly in the subject-specific and template head models. (shrink)

In this elegant new study Galen Johnson retrieves the concept of the beautiful through the framework of Merleau-Ponty’s aesthetics. Although Merleau-Ponty seldom spoke directly of beauty, his philosophy is essentially about the beautiful. In Johnson’s formulation, the ontology of Flesh as element and the ontology of the Beautiful as elemental are folded together, for Desire, Love, and Beauty are part of the fabric of the world’s element, Flesh itself, the term at which Merleau-Ponty arrived to replace Substance, Matter, or (...) Life as the name of Being. Merleau-Ponty’s _Eye and Mind _is at the core of the book, so Johnson engages, as Merleau-Ponty did, the writings and visual work of Paul Cézanne, Auguste Rodin, and Paul Klee, as well as Rilke’s commentary on Cézanne and Rodin. From these widely varying aesthetics emerge the fundamental themes of the retrieval of the beautiful: desire, repetition, difference, rhythm, and the sublime. The third part of Johnson’s book takes each of these up in turn, bringing Merleau-Ponty’s aesthetic thinking into dialogue with classical philosophy as well as Sartre, Heidegger, Nietzsche, and Deleuze. Johnson concludes his final chapter with a direct dialogue with Kant and Merleau-Ponty, and also Lyotard, on the subject of the beautiful and the sublime. As we experience with Rodin’s _Balzac_, beauty and the sublime blend into one another when the beautiful grows powerful, majestic, mysterious, and transcendent. (shrink)

Where we begin: from Mennonite to Manhattan -- How we know: the quest for certainty -- What there is: the nature of existence -- What's divine: the experience of God -- Who we are: the human challenge -- Keeping the faith: the necessity of religion -- What we receive: the discipline of gratitude -- How we should live: the source of ethics -- What we owe: an ethic of gratitude -- When we're satisfied: ultimate meaning.

In lieu of an abstract, here is a brief excerpt of the content:Dwelling in the GapsGalen SanderlinHave you ever wondered what it would be like to be a mythical being? As a hermaphrodite, I exist in a culture that sees only male or female. Those of us who don’t fit into the rigid sex binary are left out of many of the protections offered to our cousins who more neatly fit the two categories. This leaves an enormous gap in cultural (...) definitions and societal acceptance of my fundamental being.My journey has three main threads: 1) My personal and often rocky self–development, as I have come to understand and accept what it means to be a hermaphrodite, and finding others of my tribe; 2) recognizing the harm done by my medical treatment and actively seeking to change how the medical system treats hermaphrodites, starting from birth onwards; and 3) identifying what was done to me as a human rights violation.I was born in January of 1975. No genetic test was done at the time. My body looked male and my assigned sex/gender was male. As a child, I gravitated toward “male” toys. In 1989, a rural– MD noted that I was not experiencing puberty like my peers and she recommended that my parents take me to a teaching hospital in Seattle for tests. A pediatrician referred me to the adolescent medical division, and from there I was referred to an endocrinologist. After conducting many invasive tests, including drawing blood and comparing my testicles to a bead ring of ersatz testicles, the endocrinologist diagnosed me with Klinefelter’s Syndrome and a karyotype of 47,XXY. I was prescribed testosterone injections to affirm and strengthen the male identity I was assigned at birth and to prevent my body from developing secondary female sex characteristics (breasts and hips).Soon after the shots started I bulked up, adding muscle and hair everywhere. I also became dangerously aggressive and moody. I began to have serious self–esteem issues and a drastic increase in risk–taking behavior as my body was subjected to medical intervention that my parents innocently followed.The prescribed hormone treatment fractured my psyche—what I know now to be a common defense mechanism experienced in trauma survivors. The portion of my consciousness that existed prior to testosterone became deeply buried to prevent harm, and I experienced the emergence of a new “entity.” With each change in prescription, new fractures occurred: testosterone cypionate to enanthate shots, to patches, to gels.The physicians did not consider my feelings or preferences during recommendations or treatment. I feel I was forced into a “male” body based on a medical emergency they created to ease societal concerns.Last February I decided to stop hiding. Tearing the mask off has brought a flood of emotions hidden behind old traumas. I’d been living openly as an intersex person, but still deeply closeted, if not from the public—worse, from myself.Here is the writing that came pouring out of me as I’ve been accessing my repressed memories:I felt the first stirrings of my existence in August of 1989, like a fleeting visage of a long lost lover passing just out of view. The timing of the universe—Out of the infinite we are born, but in this case the body we are to occupy was already housing many other souls. Is this some mistake? Asked to be patient I waited... Late in the year of 1989 I was borne on testosterone wings into an imaginary masculine role/body.Molded in the image of Adonis, Hermes was forced to submit. No longer sexless or ageless—lost in a sea of supposed pressures and roles. My assumed gender [End Page E10] was male. Why!?! Screaming, thrashing, and damaging all around me, no way to express the horror of being so brutally manhandled.My guide Galen/Juniper were excised from our psyche—lost behind a barrier. The only solace was a shared beat: 1,2,3,4 over and over. Was this the pounding of our heart? Thank god for our love of music least we lose ourselves entirely.Why do they insist on calling me Galen? I no longer knew who this was. I... (shrink)

BackgroundFear of abandonment and aloneness play a key role in the clinical understanding interpersonal and attachment-specific problems in patients with borderline personality disorder and has been investigated in previous functional Magnet Resonance Imaging studies. The aim of the present study was to examine how different aspects of attachment representations are processed in BPD, by using for the first time an fMRI attachment paradigm including personalized core sentences from the participants’ own attachment stories. We hypothesized that BPD patients would (...) show increased functional involvement of limbic brain regions associated with fear and pain when presented personalized attachment relevant stimuli representing loneliness compared to healthy controls.MethodsWe examined the attachment classifications of 26 female BPD patients and 26 female HC using the Adult Attachment Projective Picture System. We used an fMRI-adapted attachment paradigm to investigate the neural correlates of attachment. All participants were presented three personalized sentences extracted from their AAP attachment narrative, combined with standardized AAP pictures representing being alone or in interactive attachment situations.ResultsAs expected, the classification of unresolved attachment was significantly greater in BPD compared to HC. BPD patients showed increased fMRI-activation in brain areas associated with fear, pain, and hyperarousal than HC when presented with personalized attachment-relevant alone stimuli. In particular, pictures with monadic attachment situations induced greater anterior medial cingulate cortex, anterior insula, amygdala, thalamus and superior temporal gyrus activation in the patient group.ConclusionThe results point to increased fMRI-activation in areas processing emotional distress and painful experiences in BPD patients. In particular, the emotional cascade reflecting attachment distress was evoked by combining monadic pictures, representing abandonment and aloneness, with the patients’ personalized narrative material. Our results confirmed and replicated previous results that illustrate once again the high relevance of aloneness and feelings of abandonment for BPD in the context of attachment trauma. Moreover, our results support the hypothesis of hypermentalization in response to attachment distress as a core feature of social-cognitive impairment in BPD associated with common treatment implications across different therapeutic orientations. (shrink)

From the nineteen sixties onwards a branch of philosophy of science has come to development, called history-oriented philosophy of science. This development constitutes a reaction on the then prevailing logical empiricist conception of scientific knowledge. The latter was increasingly seen as suffering from insurmountable internal problems, like e. g. the problems with the particular "observational-theoretical distinction" on which it drew. In addition the logical empiricists' general approach was increasingly criticized for two external shortcomings. Firstly, the examples of scientific (...) knowledge that the logical empiricists were focusing on were con sidered as too simplistic to be informative on the nature of real life science. Secondly, it was felt that the attention of these philosophers of science was restricted to the static aspects of scientific knowledge, while neglecting its developmental aspects. History-oriented philosophy of science has taken up the challenge implicit in the latter two criticisms, i. e. to develop accounts of science that would be more adequate for understanding the development 1 of real life science. One of the more successful products of this branch of philosophy of science is Lakatos's theory of scientific development, sometimes called the "methodology of scientific research programmes". This theory conceives science as consisting of so called research program mes developing in time, and competing with each other over the issue which one generates the best explan~tions of the phenomena that they address. (shrink)

This paper argues that ability to do otherwise (in the compatibilist sense) at the moment of initiation of action is a necessary condition of being able to act at all. If the argument is correct, it shows that Harry Frankfurt never provided a genuine counterexample to the 'principles of alternative possibilities' in his 1969 paper ‘Alternate Possibilities and Moral Responsibility’. The paper was written without knowledge of Frankfurt's paper.

According to standard compatibilist accounts of freedom, human beings act freely just so long as they are, when they act, free from constraints of certain specified kinds. Such accounts of freedom are examples of what one may call Constraint Compatibilism (CC). I will argue that, properly understood, CC entails not only that we are virtually always able to act freely, but also that virtually all if not all our actual actions are free. The suggestion is not so much that (...) this is a hitherto unnoticed consequence of CC, but, rather, that there is a certain way of conceiving of freedom implicit in CC that has not been taken sufficiently seriously. (shrink)

Intentionality is an essentially mental, essentially occurrent, and essentially experiential phenomenon. Any attempt to characterize intentionality that detaches it from conscious experience faces two insuperable problems. First, it is obliged to concede that almost everything has intentionality—all the way down to subatomic particles. Second, it has the consequence that everything that has intentionality has far too much of it—perhaps an infinite amount. The key to a satisfactory and truly naturalistic theory of intentionality is a realistic conception of naturalism and (...) a properly developed understanding of the phenomenon of cognitive experience. (shrink)

Crucial to the establishment of a scientific discipline is a body of knowledge organized around a set of instruments, interpretive techniques, and regimes of training in their application. In this paper, we trace the involvement of scientists and engineers at Varian Associates in the development of nuclear magnetic resonance spectrometers from the first demonstrations of the NMR phenomenon in 1946 to the definitive takeoff of NMR as a chemical discipline by the mid-1960s. We examine the role of (...) Varian scientists in constructing several models of NMR instruments for research scientists in the 1950s and the Varian efforts to influence the adoption of NMR as a standard tool for chemical analysis through Varian-supported publications, participation in scientific meetings, collaborations with academic chemists, workshops, and postdoctoral fellowships. Special attention is devoted to the development of the Varian A-60, the first commercial NMR instrument intended for the broadly trained chemist rather than a custom-built tool for the research specialist. Drawing on an examination of the use-rate of NMR instruments in chemical literature, the assessment of NMR in the chemical review literature by practitioners, and indicators of the establishment of a suitable funding environment for the growth of physics-based scientific instrumentation in the post-Sputnik era, we argue that the establishment of NMR as a discipline coincided with the adoption of the A-60 in the mid-1960s. During the period of our study, Varian Associates was a primary military contractor. This paper is intended to contribute to recent interest in the relation of military fundingto scientific enterprise during the Cold War and to the larger question of university-industry interactions in the growth of knowledge. (shrink)

Beginning from Klee’s statement on truth in self-portraiture that his faces are truer than real ones and Cézanne’s promise to tell us the truth in painting, we consider the origins of truth in art for the philosophy of Merleau-Ponty. We discover that truth in perception, in life, and incarnate existence, as in art, originates from bodily movement. Similar to Heidegger’s argument in “The Origin of the Work of Art,” a truth happens between the work and painter, between the (...) work and viewer, and is not limited to the domain of language, but words and symbols mix together with colors and forms, as in the paintings of Klee. Similar to Husserl’s argument in “The Origin of Geometry,” the originary sense of art, like geometry, is an interweaving of world, intersubjectivity, speech, and writing that achieves a more “militant” truth than mere logical propositions. Truth is marked by its endurance, mobility, agility, subtlety, and depth. These interweavings mean there is no single origin of truth in art and life but a plurality of origins in movement, pleasures, and desires for the becoming of creation. (shrink)

Neurofeedback is a complex learning scenario, as the task consists of trying out mental strategies while processing a feedback signal that signifies activation in the brain area to be self-regulated and acts as a potential reward signal. In an attempt to dissect these subcomponents, we obtained whole-brain networks associated with efficient self-regulation in two paradigms: parallel, where the task was performed concurrently, combining feedback with strategy execution; and serial, where the task was performed consecutively, separating feedback processing from strategy (...) execution. Twenty participants attempted to control their anterior midcingulate cortex using functional magnetic resonance imaging NF in 18 sessions over 2 weeks, using cognitive and emotional mental strategies. We analyzed whole-brain fMRI activations in the NF training runs with the largest aMCC activation for the serial and parallel paradigms. The equal length of the strategy execution and the feedback processing periods in the serial paradigm allows a description of the two task subcomponents with equal power. The resulting activation maps were spatially correlated with functionally annotated intrinsic connectivity brain maps. Brain activation in the parallel condition correlates with the basal ganglia network, the cingulo-opercular network, and the frontoparietal control network ; brain activation in the serial strategy execution condition with the default mode network, the FPCN, and the visual processing network; while brain activation in the serial feedback processing condition predominantly with the CON, the DMN, and the FPCN. Additional comparisons indicate that BG activation is characteristic to the parallel paradigm, while supramarginal gyrus and superior temporal gyrus activations are characteristic to the serial paradigm. The multifaceted view of the subcomponents allows describing the cognitive processes associated with strategy execution and feedback processing independently in the serial feedback task and as combined processes in the multitasking scenario of the conventional parallel feedback task. (shrink)

The scientific relationship among self, mind and brain is still not clearly known. Self’s subjective experience of perception and cognition of words, feelings, thoughts etc. is supported by the integrity of human brain. Consequently, neuroscientists, psychologists, psychiatrists, physicists and philosophers have been investigating to find the scientific relationship between mind and brain, consciousness and quantum physics. Recent experimental evidence suggests that the neural correlate of consciousness is located in certain parts of the cortico-thalamic system. But it is not known specifically (...) which parts of the human brain are involved in the human cognitive activity. In this study, the author proposed a tree-pattern architecture of the cerebral neural substrate in cognitive understanding of words, feelings, and thoughts on the basis of the author’s hypothesis of the ultron-logotron theory to explain the neural correlate of consciousness. (shrink)

This paper initiates a phenomenological study of the aesthetics of forest and wood in three main phases. First, we consider the modalities of wood’s sensuousness and argue against the formalist tradition that restricts aesthetic appreciation to visual forms. Second, we examine the structural, eidetic features of hand-made wooden objects in the “second life” of trees. Third, we engage in reflections on the communities gathered by the first and second lives of trees. These themes outline an aesthetics of the beautiful, the (...) given, and the gathering. We take philosophical inspiration from Merleau-Ponty throughout, and in the end, also Thoreau. (shrink)

This paper initiates a phenomenological study of the aesthetics of forest and wood in three main phases. First, we consider the modalities of wood’s sensuousness and argue against the formalist tradition that restricts aesthetic appreciation to visual forms. Second, we examine the structural, eidetic features of hand-made wooden objects in the “second life” of trees. Third, we engage in reflections on the communities gathered by the first and second lives of trees. These themes outline an aesthetics of the beautiful, the (...) given, and the gathering. We take philosophical inspiration from Merleau-Ponty throughout, and in the end, also Thoreau. (shrink)

Mazisgives us a new reading of Merleau-Ponty’s overall writings, a monumental work of vast scope with an original thematic reading of Merleau-Ponty’s thought. Its overall structure is revealed by its subtitle: elucidating the depth of silence, taking it as normative for ethics, reformulating perception as imaginal, concluding with a poetics of philosophy. The book offers us a Merleau-Ponteanethics of “felt solidarity” and “lateral unity” through developing a sharp opposition between the ethics of Merleau-Ponty and Levinasregarding the “face” and the face-to-face, (...) and a new understanding of the inspiration Merleau-Ponty received from the novels of Antoine de Saint-Exupéry.By “face of the world,” Mazismeans to highlight the “physiognomic character” of perception, which means perceiving the overall form or shape of things that is suggestive and invites further attention. Merleau-Ponty’s French term, translated as “face,” is the word figure. In other words, to speak of the “face of the world” is new way of speaking of the “flesh of the world,”with a particularly poignant ethical edge about attentiveness and respect.Ultimately, what is at stake is the whole way of entering into and conducting the philosophical enterprise. Philosophy requires a qualitative language to articulate a qualitative world. This is poetic language and poetic phenomenology. This work commands our attention in a world that is increasingly “face blind” to the expressiveness of the world, not only of persons, but also of other living organisms, even the physiognomy of institutions and nature itself.Mazis nous offre une nouvelle lecture de l’oeuvre de Merleau-Ponty. Il s’agit d’un ouvrage monumental et ambitieux offrant une lecture originale de la pensée merleau-pontienne. La structure d’ensemble s’annonce dans le sous-titre : éclairer la profondeur du silence, l’assumer en tant que norme pour une éthique, reformuler la perception en tant qu’imaginale, conclure avec une poétique de la philosophie. Le livre esquisse ainsi une éthique merleau-pontienne de la « solidarité sentie » et de l’« unité latérale » en développant une opposition nette entre l’éthique de Merleau-Ponty et de Levinas, par rapport à la question du « visage » et du « face-à-face », ainsi qu’une nouvelle compréhension de l’inspiration que Merleau-Ponty a reçu des romans d’Antoine de Saint-Exupéry.Par « visage du monde », Mazis nomme le « caractère physionomique » de la perception, c’est-à-dire le fait de percevoir l’ensemble ou la forme des choses en tant qu’elle est allusive et nous invite à une attention ultérieure. Mazis traduit ainsi le terme figure. Parler d’un « visage du monde » est une manière nouvelle pour parler d’une « chair du monde », avec une insistance particulière sur l’attention et le respect. Enfin, ce qui est en jeu est un nouveau moyen d’entrer et de conduire l’entreprise philosophique. La philosophie demande un langage qualitatif afin de pouvoir articuler un monde qualitatif : un langage poétique et une phénoménologie poétique. Un tel travail demande notre attention par rapport à un monde qui est en train de devenir de plus en plus insensible vis-à-vis de l’expressivité du monde, non seulement des personnes, mais aussi des autres organismes vivants, de la physionomie des institutions et de la nature elle-même.Mazis offre una nuova lettura degli scritti di Merleau-Ponty nel loro complesso, in un lavoro monumentale e dall’orizzonte ampio che ripercorre il pensiero del filosofo secondo un taglio tematico originale. La struttura globale dell’opera si annuncia nel suo sottotitolo: essa esplora la profondità del silenzio, assume quest’ultimo come normativo in termini etici, riformula la percezione come immaginale, e si conclude con una poetica della filosofia. Il libro tratteggia un’etica merleau-pontiana della “solidarietà percepita” e dell’“unità laterale” che viene ricostruita attraverso una contrapposizione netta tra l’etica di Merleau-Ponty e quella di Lévinas in riferimento al “volto” e al “faccia a faccia con l’altro”; offre inoltre un’interpretazione nuova degli spunti ricavati da Merleau-Ponty dai romanzi di Antoine de Saint-Exupéry.Attraverso la formula “volto del mondo”, Mazis intende evidenziare il “carattere fisiognomico” della percezione, che significa percepire i contorni o la forma complessiva delle cose in quanto suggestiva e in grado di suscitare l’attenzione. Il termine francese di Merleau-Ponty tradotto come “volto” è figure. In altri termini, parlare di “volto del mondo” è un nuovo modo per riferirsi alla “carne del mondo”, con un richiamo etico particolarmente marcato al riguardo e al rispetto.In ultima analisi, ciò che è in gioco è un modo completamente nuovo di accedere e imprimere una direzione all’impresa della filosofia. Questa richiede un linguaggio qualitativo per articolare un mondo qualitativo. Ovvero un linguaggio poetico e una fenomenologia poetica. Questo volume si impone alla nostra attenzione in un mondo sempre più affetto da “cecità” nei confronti del volto e dunque sempre più insensibile all’espressività del mondo, non soltanto nei confronti delle persone, ma anche degli organismi viventi e persino della fisiognomica delle istituzioni e della natura stessa. (shrink)

Merleau-Ponty has long been known as one of the most important philosophers of aesthetics, yet most discussions of his aesthetics focus on visual art. This book corrects that balance by turning to Merleau-Ponty's extensive engagement with literature. From Proust, Merleau-Ponty developed his conception of "sensible ideas," from Claudel, his conjoining of birth and knowledge as "co-naissance," from Valéry came "implex" or the "animal of words" and the "chiasma of two destinies." Literature also provokes the questions of expression, (...) metaphor, and truth and the meaning of a Merleau-Pontian poetics. The poetic of Merleau-Ponty is, the book argues, a poetic of the flesh, a poetic of mystery, and a poetic of the visible in its relation to the invisible. Ultimately, theoretical figures or "figuratives" that appear at the threshold between philosophy and literature enable the possibility of a new ontology. What is at stake is the very meaning of philosophy itself and its mode of expression. (shrink)

This collection of philosophical papers reflects on the existence and nature of the self. A collection of philosophical papers devoted to the subject of the self. Reflects on key questions about the existence and nature of the self. Comprises contributions from leading authorities in the field: Barry Dainton, Ingmar Persson, Marya Schechtman, Galen Strawson, Bas van Fraassen, and Peter van Inwagen.

ObjectivePrevious studies have demonstrated altered brain activity in strabismic amblyopia. In this study, low-frequency repetitive transcranial magnetic stimulation was applied in children with strabismic amblyopia after they had undergone strabismus surgery. The effect of rTMS was investigated by measuring the changes of brain features using the amplitude of low-frequency fluctuation.Materials and MethodsIn this study, 21 SA patients were recruited based on their age, weight, and sex. They all had SA in their left eyes and they received rTMS treatment one (...) month after strabismus surgery. Their vision before and after surgery were categorized as pre-rTMS and post-rTMS. All participants received rTMS treatment, underwent magnetic resonance imaging, and their data were analyzed using the repeated measures t-test. The team used correlation analysis to explore the relationship between logMAR visual acuity and ALFF.ResultsPre- versus post-rTMS values of ALFF were significantly different within individuals. In the POT group, ALFF values were significantly decreased in the Angular_R, Parietal_Inf_L, and Cingulum_Mid_R while ALFF values were significantly increased in the Fusiform_R and Frontal_Inf_Orb_L compared to the PRT stage.ConclusionOur data showed that ALFF recorded from some brain regions was changed significantly after rTMS in strabismic amblyopes. The results may infer the pathological basis of SA and demonstrate that visual function may be improved using rTMS in strabismic amblyopic patients. (shrink)

The solution structures of several small proteins have recently been determined from high‐resolution nuclear magnetic resonance data. The principal features of the methods available to do this are outlined here, together with the advantages, limitations and future prospects of the technique.

Investigation of the origin and function of three magnets from I. I. Rabi's laboratory at Columbia University leads to a closer inquiry into the early history of molecular beam evaluations of the angular momenta and magnetic moments of atomic nuclei than has been undertaken heretofore. The resulting insights into the background and the course of Rabi's research programme would probably not have occurred without the orientation enforced by these artifacts.

Objective: Patients with hypochondriasis hold unexplainable beliefs and a fear of having a lethal disease, with poor compliances and treatment response to psychotropic drugs. Although several studies have demonstrated that patients with hypochondriasis demonstrate abnormalities in brain structure and function, gray matter volume and functional connectivity in hypochondriasis still remain unclear.Methods: The present study collected T1-weighted and resting-state functional magnetic resonance images from 21 hypochondriasis patients and 22 well-matched healthy controls. We first analyzed the difference in the (...) GMV between the two groups. We then used the regions showing a difference in GMV between two groups as seeds to perform functional connectivity analysis. Finally, a support vector machine was applied to the imaging data to distinguish hypochondriasis patients from HCs.Results: Compared with the HCs, the hypochondriasis group showed decreased GMV in the left precuneus, and increased GMV in the left medial frontal gyrus. FC analyses revealed decreased FC between the left medial frontal gyrus and cuneus, and between the left precuneus and cuneus. A combination of both GMV and FC in the left precuneus, medial frontal gyrus, and cuneus was able to discriminate the hypochondriasis patients from HCs with a sensitivity of 0.98, specificity of 0.93, and accuracy of 0.95.Conclusion: Our study suggests that smaller left precuneus volumes and decreased FC between the left precuneus and cuneus seem to play an important role of hypochondriasis. Future studies are needed to confirm whether this finding is generalizable to patients with hypochondriasis. (shrink)

Naturalistic stimuli, including movie, music, and speech, have been increasingly applied in the research of neuroimaging. Relative to a resting-state or single-task state, naturalistic stimuli can evoke more intense brain activities and have been proved to possess higher test–retest reliability, suggesting greater potential to study adaptive human brain function. In the current research, naturalistic functional magnetic resonance imaging (N-fMRI) has been a powerful tool to record brain states under naturalistic stimuli, and many efforts have been devoted to study (...) the high-level semantic features from spatial or temporal representations via N-fMRI. However, integrating both spatial and temporal characteristics of brain activities for better interpreting the patterns under naturalistic stimuli is still underexplored. In this work, a novel hybrid learning framework that comprehensively investigates both the spatial (via Predictive Model) and the temporal [via convolutional neural network (CNN) model] characteristics of the brain is proposed. Specifically, to focus on certain relevant regions from the whole brain, regions of significance (ROS), which contain common spatial activation characteristics across individuals, are selected via the Predictive Model. Further, voxels of significance (VOS), whose signals contain significant temporal characteristics under naturalistic stimuli, are interpreted via one-dimensional CNN (1D-CNN) model. In this article, our proposed framework is applied onto the N-fMRI data during naturalistic classical/pop/speech audios stimuli. The promising performance is achieved via the Predictive Model to differentiate the different audio categories. Especially for distinguishing the classic and speech audios, the accuracy of classification is up to 92%. Moreover, spatial ROS and VOS are effectively obtained. Besides, temporal characteristics of the high-level semantic features are investigated on the frequency domain via convolution kernels of 1D-CNN model, and we effectively bridge the “semantic gap” between high-level semantic features of N-fMRI and low-level acoustic features of naturalistic audios in the frequency domain. Our results provide novel insights on characterizing spatiotemporal patterns of brain activities via N-fMRI and effectively explore the high-level semantic features under naturalistic stimuli, which will further benefit the understanding of the brain working mechanism and the advance of naturalistic stimuli clinical application. (shrink)